Sorafenib is an oral targeted kinase inhibitor used to treat advanced renal cell carcinoma (kidney cancer), unresectable hepatocellular carcinoma (liver cancer), and radioactive iodine-resistant differentiated thyroid cancer.

How to Take It

• Form & Dosage: It is available as a 200 mg tablet. The standard dosage is typically 400 mg (two tablets) taken twice daily.
• Administration: Tablets should be swallowed whole with a glass of water. It is generally recommended to take sorafenib either on an empty stomach or with a low-to-moderate-fat meal, as a high-fat meal can reduce the drug’s absorption and efficacy.

Common Side Effects
Patients taking sorafenib may experience several side effects. Common ones include:

• Dermatological: Hand-foot skin reaction (redness, pain, or peeling on the palms and soles), rash, and dry skin.
• Gastrointestinal: Diarrhea, nausea, vomiting, and decreased appetite.
• Systemic: Fatigue, weakness, and weight loss.
• Cardiovascular: High blood pressure (hypertension).